The ocean quahog clam shows exceptional longevity. One specimen called "Ming" was estimated to live up to 507 years in the wild. One study found that in animals aged 4-192 years, antioxidant enzymes declined rapidly in the first 25 years, which includes the growth and sexual maturity stages, but afterwards remained stable for over 150 years.
In addition, the level of oxidatively damaged proteins in the heart does not change significantly up to 120 years of age.
In addition, the level of oxidatively damaged proteins in the heart does not change significantly up to 120 years of age.
The ocean quahog clam has very high proteome stability, especially in comparison to short-lived mammals. In one study it was demonstrated these animals had no increase in global proteome unfolding in response to several stressors.
The extreme maximum lifespan of the ocean quahog clam appears to be independent of telomere dynamics. Telomere lengths show no change with age, with no significant differences between populations and tissues. Telomerase activity is also highly heterogenous and does not correlate with age or population habitat.
A study that measured four age-related damage markers (protein oxidation, lipid oxidation, nucleic acid oxidation, and protein stability) reported that only nucleic acid oxidation accumulates with age in these animals. Though more detailed studies are warranted, it appears this species is a case of negligible senescence.
The extreme maximum lifespan of the ocean quahog clam appears to be independent of telomere dynamics. Telomere lengths show no change with age, with no significant differences between populations and tissues. Telomerase activity is also highly heterogenous and does not correlate with age or population habitat.
A study that measured four age-related damage markers (protein oxidation, lipid oxidation, nucleic acid oxidation, and protein stability) reported that only nucleic acid oxidation accumulates with age in these animals. Though more detailed studies are warranted, it appears this species is a case of negligible senescence.
http://genomics.senescence.info/species/entry.php?species=Arctica_islandica
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