the Horseshoe Crab has lysate blood (copper based) - this is quite rare

The blood of these arthropods (horseshoe crabs) does not contain hemoglobin –the stuff responsible for transporting oxygen within red blood cells of vertebrates like us humans. Instead, horseshoe crabs use copper-containing hemocyanin for oxygen transport and thus, their unique blood has a beautiful blue color. In the 1960’s, John Hopkins University researcher Dr. Frederik Bang observed that massive clotting occurred when common marine bacteria were injected into the bloodstream of the North American horseshoe crab. Because of the specie’s impressive evolutionary history and relatively subtle changes in appearance and physiology, horseshoe crabs have a compound in their blood called Limulus Amebocyte Lysate (LAL) to rapidly attack infections in lieu of an immune system. LAL clots around the “bad germs” such as bacterial endotoxins, viruses, and fungi. In other words, the blood turns into a jelly-like substance. Due to this discovery, LAL was used to medical advantage, since it could act as an international standard screening testfor bacterial contamination and toxins in biomedical applications.

http://www.onegreenplanet.org/animalsandnature/stealing-blood-of-horseshoe-crabs/